Elected: 2020
Discipline: Cell and Molecular Biology
Professor Miratul Muqit
Professor of Experimental Neurology, University of Dundee
Miratul Muqit made a major contribution to the discovery of PINK1 protein kinase mutations as a cause of Parkinson’s disease in 2004. His research has since revealed how PINK1 and the ubiquitin E3 ligase Parkin function together in removing damaged mitochondria by autophagy or ‘mitophagy’. This hitherto unknown mitochondrial recycling pathway is highly conserved in nearly all cell types of the body including neurons. The molecular mechanisms elucidated by Miratul’s research are now being investigated by biotechnology companies as new therapeutic strategies against Parkinson’s and ageing.
Miratul is a physician scientist who graduated in Medicine with Honours from the University of Edinburgh. Following medical training on the Hammersmith Hospital rotation he completed specialist Neurology training in London including the National Hospital for Neurology and Neurosurgery at Queen Square. He has been based at the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee since 2008. His research has been recognised by several awards .