Fellow: Gunn-Moore
Elected: 2023
Discipline: Cell and Molecular Biology
Professor Frank Gunn-Moore
Professor of Molecular Neurobiology, University of St Andrews
Professor Frank Gunn-Moore is an academic and researcher in the field of neurodegeneration and dementia research. His group have made discoveries in understanding the cellular and biochemical mechanisms involved in the early stages of Alzheimer’s disease (specifically linking mitochondrial and synaptic dysfunction), where his group has pioneered new models (including the first identification that cetaceans – whales and dolphins – also show similar pathology) and identified potential therapeutic targets with resultant industrial collaboration for novel inhibitors. Using both molecular and novel biophysical techniques, he has also discovered novel signalling pathways that are involved in the growth and development of mammalian neurons, including the first identification of the gene FRMD6/Willin as an upstream component of the Hippo pathway, which prior to his work was thought to be involved only in cancer. In collaboration, he has developed novel optical technology with the production of patents that have been further developed by industry. The interdisciplinary breadth and depth of his research is illustrated by publication of >150 research papers across journals in Biology, Chemistry or Physics.